Abstract
In a recent issue of Cell, Ayad et al. (2003) report the identification of a novel F box protein Tome-1, which mediates the destruction of mitosis-inhibitory kinase wee1 via E3 ligase SCF. Tome-1 itself is targeted for degradation by APC in G1. This synergy of destructive action by APC and SCF has important implications for timely entry into mitosis.
MeSH terms
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Anaphase-Promoting Complex-Cyclosome
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Animals
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CDC2 Protein Kinase / genetics
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CDC2 Protein Kinase / metabolism
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism*
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Cyclin B / genetics
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Cyclin B / metabolism
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Eukaryotic Cells / enzymology*
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Humans
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Ligases / genetics
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Ligases / metabolism
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Mitosis / genetics*
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Nuclear Proteins*
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Peptide Synthases / genetics
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Peptide Synthases / metabolism
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / metabolism*
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SKP Cullin F-Box Protein Ligases
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Schizosaccharomyces pombe Proteins
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Ubiquitin-Protein Ligase Complexes*
Substances
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CDCA3 protein, human
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Cell Cycle Proteins
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Cyclin B
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Nuclear Proteins
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Schizosaccharomyces pombe Proteins
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Ubiquitin-Protein Ligase Complexes
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Anaphase-Promoting Complex-Cyclosome
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SKP Cullin F-Box Protein Ligases
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wee1 protein, S pombe
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Protein-Tyrosine Kinases
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WEE1 protein, human
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CDC2 Protein Kinase
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Ligases
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Peptide Synthases