Tome-1, wee1, and the onset of mitosis: coupled destruction for timely entry

Mol Cell. 2003 Apr;11(4):845-6. doi: 10.1016/s1097-2765(03)00149-7.

Abstract

In a recent issue of Cell, Ayad et al. (2003) report the identification of a novel F box protein Tome-1, which mediates the destruction of mitosis-inhibitory kinase wee1 via E3 ligase SCF. Tome-1 itself is targeted for degradation by APC in G1. This synergy of destructive action by APC and SCF has important implications for timely entry into mitosis.

Publication types

  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • CDC2 Protein Kinase / genetics
  • CDC2 Protein Kinase / metabolism
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Cyclin B / genetics
  • Cyclin B / metabolism
  • Eukaryotic Cells / enzymology*
  • Humans
  • Ligases / genetics
  • Ligases / metabolism
  • Mitosis / genetics*
  • Nuclear Proteins*
  • Peptide Synthases / genetics
  • Peptide Synthases / metabolism
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / metabolism*
  • SKP Cullin F-Box Protein Ligases
  • Schizosaccharomyces pombe Proteins
  • Ubiquitin-Protein Ligase Complexes*

Substances

  • CDCA3 protein, human
  • Cell Cycle Proteins
  • Cyclin B
  • Nuclear Proteins
  • Schizosaccharomyces pombe Proteins
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • SKP Cullin F-Box Protein Ligases
  • wee1 protein, S pombe
  • Protein-Tyrosine Kinases
  • WEE1 protein, human
  • CDC2 Protein Kinase
  • Ligases
  • Peptide Synthases