Abstract
In skeletal muscle, contractile force can be transmitted laterally between the z-disks and M-lines of neighboring myofibrils, across the sarcolemma, and through the extracellular matrix to the tendon. Here we examine the data that support this model and the sarcolemmal properties and structures, termed "costameres," that are consistent with it.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Actin Cytoskeleton / physiology
-
Actin Cytoskeleton / ultrastructure
-
Animals
-
Cytoskeleton / physiology
-
Cytoskeleton / ultrastructure*
-
Dystrophin / metabolism
-
Extracellular Matrix / physiology
-
Humans
-
Immunohistochemistry
-
Integrins / physiology
-
Models, Anatomic
-
Muscle Contraction / physiology*
-
Muscle, Skeletal / physiology*
-
Muscle, Skeletal / ultrastructure*