Abstract
Two new prenylflavanones, propolin A (2) and propolin B (3), were isolated and characterized from Taiwanese propolis. Both compounds were found to have cytotoxic properties against three cancer cell lines. DNA content analyses and DNA fragmentation indicated that propolin A (2) efficiently induced apoptosis in cancer cell lines, but had no effect on the cell cycle program. Furthermore, both propolin A (2) and B (3) are potential antioxidant agents and show strong scavenging effects against most types of free radicals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology
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Apoptosis
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Bees / chemistry*
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DNA / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Glioma
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HL-60 Cells / drug effects
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Humans
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Melanoma
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Propolis / chemistry*
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Taiwan
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Antioxidants
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Flavonoids
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Free Radical Scavengers
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propolin A
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propolin B
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DNA
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Propolis