New stigmastane sterols from Ajuga salicifolia

J Nat Prod. 2003 Apr;66(4):461-5. doi: 10.1021/np020427e.

Abstract

A new sterol, ajugasalicigenin (1), and three new sterol glycosides, ajugasaliciosides F-H (2-4), were isolated and characterized from the aerial parts of Ajuga salicifolia. Compounds 1-4 are further representatives of the stigmastane type of sterols. Their cytotoxicity against KB (HeLa) and Jurkat T cancer cells was evaluated.

MeSH terms

  • Ajuga / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drug Screening Assays, Antitumor
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Jurkat Cells / drug effects
  • KB Cells / drug effects
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal / chemistry*
  • Stereoisomerism
  • Sterols / chemistry
  • Sterols / isolation & purification*
  • Sterols / pharmacology
  • Tumor Cells, Cultured / drug effects
  • Turkey

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Sterols
  • ajugasalicigenin