Antisense oligonucleotide inhibitors of MDM2 oncogene expression

Methods Mol Med. 2003:85:205-22. doi: 10.1385/1-59259-380-1:205.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Blotting, Western
  • Colonic Neoplasms / drug therapy
  • Colonic Neoplasms / genetics
  • DNA Damage
  • Female
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Mice
  • Mice, Nude
  • Mice, SCID
  • Neoplasm Proteins / biosynthesis*
  • Neoplasm Proteins / genetics
  • Nuclear Proteins*
  • Oligodeoxyribonucleotides, Antisense / pharmacology*
  • Oligodeoxyribonucleotides, Antisense / therapeutic use
  • Oncogenes / drug effects*
  • Proto-Oncogene Proteins / biosynthesis*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins c-mdm2
  • Recombinant Fusion Proteins / biosynthesis
  • Specific Pathogen-Free Organisms
  • Thionucleotides / pharmacology
  • Thionucleotides / therapeutic use
  • Transfection
  • Tumor Cells, Cultured / drug effects
  • Xenograft Model Antitumor Assays

Substances

  • Neoplasm Proteins
  • Nuclear Proteins
  • Oligodeoxyribonucleotides, Antisense
  • Proto-Oncogene Proteins
  • Recombinant Fusion Proteins
  • Thionucleotides
  • Mdm2 protein, mouse
  • Proto-Oncogene Proteins c-mdm2