Abstract
Apoptosis in the heart can be triggered by ischemia and/or reperfusion depending on conditions. This may involve activation of plasma membrane death receptors and/or translocation of Bcl-2 homologous proteins to mitochondria. However, one of the main mechanisms for triggering this apoptosis appears to be mitochondrial permeability transition followed by cytochrome c release. Cytochrome c release can result in caspase activation and thus apoptosis, but also results in mitochondrial dysfunction, which might contribute to contractile dysfunction or necrosis at reperfusion.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis*
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Cytochrome c Group / metabolism
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Humans
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Ion Channels / metabolism
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Mitochondria, Heart / metabolism
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Mitochondria, Heart / physiology*
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Mitochondrial Membrane Transport Proteins
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Mitochondrial Permeability Transition Pore
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Models, Cardiovascular
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Myocardial Ischemia / metabolism*
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Myocardial Ischemia / pathology
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Myocardial Reperfusion Injury / metabolism
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Myocardial Reperfusion Injury / pathology
Substances
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Cytochrome c Group
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Ion Channels
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Mitochondrial Membrane Transport Proteins
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Mitochondrial Permeability Transition Pore