Heat shock proteins and the pancreas

J Cell Physiol. 2003 Jun;195(3):383-91. doi: 10.1002/jcp.10268.

Abstract

Heat shock proteins (HSPs) are cytoprotective molecules that help to maintain the metabolic and structural integrity of cells. In this review, we briefly discuss the regulation and function of HSPs. The review focuses on the current knowledge of pancreatic HSP induction, the HSP level changes during acute pancreatitis, the potential effects of the pre- and co-induction of HSPs in experimental acute pancreatitis, and the mechanisms by which HSPs might mediate cellular protection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Carcinoma / genetics
  • Carcinoma / metabolism
  • Chronic Disease
  • Cytoprotection
  • Heat-Shock Proteins / biosynthesis*
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / physiology*
  • Heat-Shock Response
  • Humans
  • Pancreas / metabolism*
  • Pancreatic Neoplasms / genetics
  • Pancreatic Neoplasms / metabolism
  • Pancreatitis / metabolism
  • RNA, Messenger / biosynthesis

Substances

  • Heat-Shock Proteins
  • RNA, Messenger