Tomato spotted wilt caused by thrips-vectored tomato spotted wilt virus (TSWV) is a very serious problem in peanut (Arachis hypogaea L.) production. TSWV and the thrips Frankliniella fusca and Frankliniella occidentalis, which vector the virus, present a difficult and complicated challenge from the perspectives of both epidemiology and disease management. Simply controlling the vector typically has not resulted in control of spotted wilt. No single measure can currently provide adequate control of spotted wilt where severe epidemics occur. However, interdisciplinary investigations have resulted in development of integrated management systems that make use of moderately resistant cultivars and chemical and cultural practices, each of which helps to suppress spotted wilt epidemics. Such systems have been successfully deployed in many areas for minimizing losses to this disease. The development of a spotted wilt risk index has aided greatly in relaying information on the importance of using an integrated approach for managing this disease.