Three studies investigated the effect of encouraging participants to believe in an afterlife on the relationship between mortality salience and self-esteem striving. Participants were exposed to essays arguing either in favor of or against the existence of an afterlife, and reminded about death or a control topic. Mortality salience led to increased accuracy ratings of a positive personality description (Studies 1 and 2) and increased striving for and defense of values (Study 3) among participants who read the essay arguing against an afterlife, but not among participants who read the essay in favor of it. The implications for the terror management analysis of self-esteem, the appeal of immortality beliefs, and the interplay between self-esteem striving and spiritual pursuits are discussed.