Abstract
An asymmetric formal total synthesis of diplodialide A 1a has been achieved starting from methyl acetoacetate 6 and (R)-3-buten-2-ol 7. The macrocyclic ring core of (+)-diplodialide A 1a was constructed, in an excellent yield, by using a ring-closing metathesis strategy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Chemistry, Organic / methods*
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Cyclization
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Fungi / chemistry
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Indicators and Reagents
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Lactones / analysis
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Lactones / chemical synthesis*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Stereoisomerism
Substances
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Indicators and Reagents
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Lactones
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diplodialide A