Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine

Leuk Lymphoma. 2003 Mar;44(3):531-3. doi: 10.1080/1042819021000035662.

Abstract

Hepatosplenic gammadelta T-cell lymphoma (HS-gammadeltaTCL) is an uncommon type of peripheral T-cell lymphoma, which has been associated in some cases with immunosuppression, mainly after solid organ transplants. We describe a case of HSgammadeltaTCL with a leukaemic course in a patient with Crohn's disease who had received azathioprine during the previous 5.5 years. Sinusoidal infiltration by atypical lymphocytes was observed in the liver, spleen and bone marrow and the typical cytogenetic abnormalities (isochromosome 7 and trisomy 8) were found. The patient did not respond to intensive chemotherapy. This case shows the importance of ruling out HSgammadeltaTCL in patients with hepatosplenomegaly, B-symptoms and any immunosuppressive condition.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Autoimmune Diseases / complications*
  • Autoimmune Diseases / drug therapy
  • Azathioprine / adverse effects
  • Azathioprine / therapeutic use
  • Chromosome Aberrations
  • Combined Modality Therapy
  • Crohn Disease / complications*
  • Crohn Disease / drug therapy
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Drug Combinations
  • Fatal Outcome
  • Glucosamine / analogs & derivatives*
  • Glucosamine / therapeutic use
  • Humans
  • Immunophenotyping
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Liver Neoplasms / complications*
  • Liver Neoplasms / drug therapy
  • Lymphoma, T-Cell, Peripheral / complications*
  • Lymphoma, T-Cell, Peripheral / drug therapy
  • Lymphoma, T-Cell, Peripheral / surgery
  • Male
  • Prednisone / administration & dosage
  • Receptors, Antigen, T-Cell, gamma-delta / analysis*
  • Splenectomy
  • Splenic Neoplasms / complications*
  • Splenic Neoplasms / drug therapy
  • Splenic Neoplasms / surgery
  • Sulfasalazine / therapeutic use
  • Vincristine / administration & dosage

Substances

  • Adrenal Cortex Hormones
  • Drug Combinations
  • Immunosuppressive Agents
  • Receptors, Antigen, T-Cell, gamma-delta
  • Salazopyrine
  • Sulfasalazine
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Azathioprine
  • Glucosamine
  • Prednisone

Supplementary concepts

  • CHOP protocol