A first cyclopenta[c]thiophene dimer as a new bivalent potent cytotoxic derivative

J Enzyme Inhib Med Chem. 2002 Dec;17(6):439-42. doi: 10.1080/1475636021000005730.

Abstract

Application of the bivalent approach to the cyclopenta[c]thiophene series led to a potent cytotoxic dimer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Leukemia / metabolism
  • Structure-Activity Relationship
  • Thiophenes / chemical synthesis*
  • Thiophenes / chemistry
  • Thiophenes / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Thiophenes