[Pathogenesis of choroidal neovascularization. Old concepts, new questions]

Ophthalmologe. 2003 Apr;100(4):300-5. doi: 10.1007/s00347-003-0802-6.
[Article in German]

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world but the pathogenesis remains poorly understood. Malfunction of the retinal pigment epithelium (RPE) plays a central role in the disease and leads to either choriodal atrophy or proliferation. This article reviews the current concepts of the development of choriodal atrophy and neovascularisation. Furthermore, available animal models and potential therapeutical targets are discussed.

Publication types

  • Comparative Study
  • English Abstract
  • Review

MeSH terms

  • Age Factors
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Cells, Cultured
  • Choroidal Neovascularization / complications
  • Choroidal Neovascularization / etiology*
  • Choroidal Neovascularization / genetics
  • Choroidal Neovascularization / physiopathology
  • Choroidal Neovascularization / therapy
  • Choroiditis / complications
  • Clinical Trials, Phase III as Topic
  • Controlled Clinical Trials as Topic
  • Disease Models, Animal
  • Endothelial Growth Factors / antagonists & inhibitors
  • Endothelial Growth Factors / therapeutic use
  • Eye Injuries / complications
  • Haplorhini
  • Humans
  • Intercellular Signaling Peptides and Proteins / therapeutic use
  • Interferon-gamma / therapeutic use
  • Laser Therapy
  • Lymphokines / antagonists & inhibitors
  • Lymphokines / therapeutic use
  • Macula Lutea / transplantation
  • Macular Degeneration / complications*
  • Macular Degeneration / therapy
  • Mice
  • Mice, Transgenic
  • Myopia / complications
  • Photochemotherapy
  • Pigment Epithelium of Eye / cytology
  • Rats
  • Retinal Neovascularization / etiology
  • Retinal Neovascularization / physiopathology
  • Risk Factors
  • Triamcinolone / therapeutic use
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Angiogenesis Inhibitors
  • Anti-Inflammatory Agents
  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Triamcinolone
  • Interferon-gamma