Abstract
The synthesis of tetra(hexa)hydropyrazolo[1,2-a]pyrido[3,4-d]pyridazine derivatives (14-21) and the results of pharmacological screening are described in this paper. All compounds tested were non-toxic and showed a significant analgesic action. The analgesic effects were associated with the suppression of the spontaneous locomotor activity. Furthermore most of the synthesized compounds displayed a weak antimycobacterial action in the preliminary screening.
MeSH terms
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Analgesics, Non-Narcotic / chemical synthesis*
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Analgesics, Non-Narcotic / pharmacology
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Analgesics, Non-Narcotic / toxicity
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / pharmacology
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Blood Pressure / drug effects
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Lethal Dose 50
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Mice
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Microbial Sensitivity Tests
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Motor Activity / drug effects
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Mycobacterium / drug effects
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Pain Measurement / drug effects
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Pyrazoles / chemical synthesis*
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Pyrazoles / pharmacology
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Pyrazoles / toxicity
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Pyridazines / chemical synthesis*
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Pyridazines / pharmacology
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Pyridazines / toxicity
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Rats
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Rats, Wistar
Substances
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Analgesics, Non-Narcotic
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Anti-Bacterial Agents
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Pyrazoles
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Pyridazines