Atherogenic profile in preeclampsia

Arch Gynecol Obstet. 2003 Apr;268(1):45-7. doi: 10.1007/s00404-002-0317-4. Epub 2002 May 16.

Abstract

Atherosis is accepted to underlie the pathogenesis of preeclampsia, therefore we aimed to determine malonyldialdehyde (MDA) levels as a marker of lipid peroxidation, and lipoprotein(a) (Lp(a)), apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B) levels as a marker of atherogenic profile in preeclamptic and normal pregnant women. Twenty preeclamptic and 20 gestational-age matched normal pregnant patients were enrolled in the study, mean gestational ages for the preeclamptic and the control group were 33.9+/-1.4 and 35.5+/-0.7 weeks, respectively. Blood was withdrawn from the patients soon after diagnosis, and from the controls at their routine prenatal visits. MDA levels was significantly higher in preeclamptic patients (P=0.0003), but no difference was observed in Apo A-1 and Apo B and Lp(a) levels between the 2 groups. We consider that higher MDA was due to oxidative stress seen in preeclampsia, and similar Apo A-1 and Apo B and Lp(a) levels were due to lack of systemic atherosis.

MeSH terms

  • Adult
  • Apolipoprotein A-I / blood*
  • Apolipoproteins B / blood*
  • Arteriosclerosis / blood*
  • Case-Control Studies
  • Female
  • Humans
  • Lipoprotein(a) / blood*
  • Malondialdehyde / blood*
  • Pre-Eclampsia / blood*
  • Pregnancy

Substances

  • Apolipoprotein A-I
  • Apolipoproteins B
  • Lipoprotein(a)
  • Malondialdehyde