Three new ingol diterpenes from Euphorbia nivulia: evaluation of cytotoxic activity

Veluri Ravikanth; Vanimireddy Lakshmi Niranjan Reddy; Adelli Vijender Reddy; Kodela Ravinder; Tadikamalla Prabhakar Rao; Tejomoorty Siva Ram; Kondapi Anand Kumar; Diwan Prakesh Vamanarao; Yenamandra Venkateswarlu

doi:10.1248/cpb.51.431

Three new ingol diterpenes from Euphorbia nivulia: evaluation of cytotoxic activity

Chem Pharm Bull (Tokyo). 2003 Apr;51(4):431-4. doi: 10.1248/cpb.51.431.

Authors

Veluri Ravikanth¹, Vanimireddy Lakshmi Niranjan Reddy, Adelli Vijender Reddy, Kodela Ravinder, Tadikamalla Prabhakar Rao, Tejomoorty Siva Ram, Kondapi Anand Kumar, Diwan Prakesh Vamanarao, Yenamandra Venkateswarlu

Affiliation

¹ Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India.

PMID: 12673000
DOI: 10.1248/cpb.51.431

Abstract

The latex of Euphorbia nivulia afforded three new ingol diterpenes, 3-acetyl-8-methoxyl-7-angolyl-12-hydroxylingol (7), 3,12-diacetyl-7-hydroxy-8-methoxylingol (8), and 3,12-diacetyl-7-angolyl-8-hydroxylingol (9) along with five known ingol diterpenes 2-6 and a known triterpene cyclonivulinol (1). Their structures were established by means of spectroscopic analysis. Diterpenes 2-9 were evaluated for their cytotoxic activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytotoxins / chemistry
Cytotoxins / isolation & purification
Cytotoxins / pharmacology*
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Drug Evaluation, Preclinical / methods
Euphorbia*
Humans
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plant Structures
Tumor Cells, Cultured / drug effects

Substances

Cytotoxins
Diterpenes
Plant Extracts