Abstract
A series of new S-adamantylated compounds were prepared by adamanlyl cation attack on the thiol group. The biological activity of new compounds as the inducers of TNF-alpha in genetically modified mouse melanoma cells is presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adamantane / analogs & derivatives*
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Adamantane / chemical synthesis*
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Adamantane / pharmacology*
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Animals
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Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
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Heterocyclic Compounds, 4 or More Rings / pharmacology*
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Melanoma, Experimental / genetics
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Melanoma, Experimental / metabolism*
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Mice
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Tumor Cells, Cultured
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Tumor Necrosis Factor-alpha / biosynthesis*
Substances
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Heterocyclic Compounds, 4 or More Rings
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Indicators and Reagents
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Tumor Necrosis Factor-alpha
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Adamantane