RNA-binding proteins that target the androgen receptor mRNA

IUBMB Life. 2002 Dec;54(6):345-9. doi: 10.1080/15216540216033.

Abstract

Recent efforts to elucidate mechanisms of posttranscriptional gene regulation have resulted in the description of both cis- and trans-acting factors which affect the stability and translational efficiency of specific mRNAs. Here we summarise some of the concepts in this field, with particular attention to recently discovered protein/RNA interactions involving the human androgen receptor mRNA. Such systems are of interest for their potential as targets for the modulation of protein production.

Publication types

  • Review

MeSH terms

  • Antigens, Surface*
  • Base Sequence
  • DNA-Binding Proteins
  • ELAV Proteins
  • ELAV-Like Protein 1
  • Gene Expression Regulation
  • Heterogeneous-Nuclear Ribonucleoproteins / chemistry
  • Humans
  • Models, Biological
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Protein Binding
  • RNA / metabolism
  • RNA Processing, Post-Transcriptional
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / metabolism*
  • Receptors, Androgen / metabolism*

Substances

  • Antigens, Surface
  • DNA-Binding Proteins
  • ELAV Proteins
  • ELAV-Like Protein 1
  • ELAVL1 protein, human
  • Heterogeneous-Nuclear Ribonucleoproteins
  • PCBP1 protein, human
  • RNA, Messenger
  • RNA-Binding Proteins
  • Receptors, Androgen
  • RNA