Abstract
Adenovirus dodecahedron is a virus-like particle composed of only two viral proteins of human adenovirus serotype 3 that are responsible for virus attachment and internalization. We show here that this dodecameric particle, devoid of genetic information, efficiently penetrates human cells and can deliver large multimeric proteins such as immunoglobulins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenoviruses, Human / genetics*
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Adenoviruses, Human / metabolism
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Animals
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Capsid / metabolism*
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Capsid Proteins / genetics
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Capsid Proteins / metabolism*
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Dimerization
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Genetic Vectors
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HeLa Cells
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Humans
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Mice
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Microscopy, Confocal
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Transduction, Genetic*
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Virion / genetics
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Virion / metabolism
Substances
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Capsid Proteins
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hexon capsid protein, Adenovirus
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penton protein, adenovirus