Adenovirus dodecahedron allows large multimeric protein transduction in human cells

J Virol. 2003 Apr;77(8):4960-4. doi: 10.1128/jvi.77.8.4960-4964.2003.

Abstract

Adenovirus dodecahedron is a virus-like particle composed of only two viral proteins of human adenovirus serotype 3 that are responsible for virus attachment and internalization. We show here that this dodecameric particle, devoid of genetic information, efficiently penetrates human cells and can deliver large multimeric proteins such as immunoglobulins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviruses, Human / genetics*
  • Adenoviruses, Human / metabolism
  • Animals
  • Capsid / metabolism*
  • Capsid Proteins / genetics
  • Capsid Proteins / metabolism*
  • Dimerization
  • Genetic Vectors
  • HeLa Cells
  • Humans
  • Mice
  • Microscopy, Confocal
  • Transduction, Genetic*
  • Virion / genetics
  • Virion / metabolism

Substances

  • Capsid Proteins
  • hexon capsid protein, Adenovirus
  • penton protein, adenovirus