Abstract
Three new sesterterpenes (1-3) were isolated from a marine sponge of the genus Spongia, and their structures were determined on the basis of spectroscopic analysis. The compounds 1-3 exhibited cytotoxicity against HeLa cells with IC(50) values of 19.5, 15.0, and 5.3 microg/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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HeLa Cells / drug effects
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Humans
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Inhibitory Concentration 50
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Japan
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Molecular Structure
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Porifera / chemistry*
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Sesterterpenes
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Stereoisomerism
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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12-O-acetyl-16-O-methylhyrtiolide
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12-O-deacetyl-12-epi-scalarin
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12-O-deacetylscalarafuran
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Antineoplastic Agents
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Sesterterpenes
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Terpenes