Three new cytotoxic sesterterpenes from a marine sponge Spongia sp

J Nat Prod. 2003 Mar;66(3):438-40. doi: 10.1021/np020497l.

Abstract

Three new sesterterpenes (1-3) were isolated from a marine sponge of the genus Spongia, and their structures were determined on the basis of spectroscopic analysis. The compounds 1-3 exhibited cytotoxicity against HeLa cells with IC(50) values of 19.5, 15.0, and 5.3 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • HeLa Cells / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Japan
  • Molecular Structure
  • Porifera / chemistry*
  • Sesterterpenes
  • Stereoisomerism
  • Terpenes / chemistry
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology
  • Tumor Cells, Cultured / drug effects

Substances

  • 12-O-acetyl-16-O-methylhyrtiolide
  • 12-O-deacetyl-12-epi-scalarin
  • 12-O-deacetylscalarafuran
  • Antineoplastic Agents
  • Sesterterpenes
  • Terpenes