Abstract
Two new carbazole alkaloids named murrayanine (1) and 8,8' '-biskoenigine (2) were isolated from Murraya koenigii. The structure elucidations for 1 and 2 were carried out on the basis of 1D and 2D NMR experiments. Compound 1 was a novel carbazole alkaloid with a rare phenylpropanyl substitution. Compound 2 was a symmetrical dimer of the carbazole alkaloid koenigine and showed antiosteoporotic activity in the CAT-B model with IC(50) 1.3 microg/mL. The synthesis of 2 from koenigine was carried out through oxidative coupling using a solid state reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Carbazoles / chemistry
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Carbazoles / isolation & purification*
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Carbazoles / pharmacology
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Cathepsin B / drug effects*
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Disease Models, Animal
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Drugs, Chinese Herbal / chemistry*
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal
Substances
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8,8' '-biskoenigine
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Alkaloids
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Anti-Infective Agents
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Antifungal Agents
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Antineoplastic Agents
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Carbazoles
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Drugs, Chinese Herbal
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carbazole
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murrayanine
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Cathepsin B