Abstract
Establishing persistent infection and resisting elimination by the host's immune system are key factors contributing to latent infection by Mycobacterium tuberculosis. Recently, bacterial determinants regulating these processes have been identified. Here, we review molecular mechanisms regulating persistent infection and discuss the highly dynamic interaction of M. tuberculosis with the host.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Carrier State / immunology*
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Carrier State / microbiology
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Disease Models, Animal
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Gene Expression Regulation, Bacterial*
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Granuloma / immunology
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Granuloma / microbiology
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Humans
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Macrophages / immunology
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Macrophages / microbiology
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Mice
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / pathogenicity*
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Mycobacterium tuberculosis / physiology
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Tuberculosis / immunology*
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Tuberculosis / microbiology
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Virulence / genetics