Novel alpha-amino-acid phenolic ester derivatives with intravenous anaesthetic activity

Andrew Cooke; Alison Anderson; Jonathan Bennett; Kirsteen Buchanan; David Gemmell; Niall Hamilton; Maurice Maidment; Petula McPhail; Donald Stevenson; Hardy Sundaram

doi:10.1016/s0960-894x(03)00025-8

Novel alpha-amino-acid phenolic ester derivatives with intravenous anaesthetic activity

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1107-10. doi: 10.1016/s0960-894x(03)00025-8.

Authors

Andrew Cooke¹, Alison Anderson, Jonathan Bennett, Kirsteen Buchanan, David Gemmell, Niall Hamilton, Maurice Maidment, Petula McPhail, Donald Stevenson, Hardy Sundaram

Affiliation

¹ Department of Medicinal Chemistry, Organon Laboratories Ltd., Newhouse, Scotland, ML1 5SH, UK. a.cooke@organon.co.uk

PMID: 12643922
DOI: 10.1016/s0960-894x(03)00025-8

Abstract

A novel series of alpha-amino-acid phenolic ester derivatives containing sulphide, sulphoxide, sulphone, ester and amide side chains were prepared and shown to display potent intravenous anaesthetic activity.

MeSH terms

Amino Acids / chemical synthesis*
Amino Acids / pharmacology*
Anesthetics, Intravenous / chemical synthesis*
Anesthetics, Intravenous / pharmacology*
Animals
Esters
GABA-A Receptor Antagonists
Male
Mice
Phenols / chemical synthesis*
Phenols / pharmacology*
Postural Balance / drug effects
Propofol / pharmacology
Reflex / drug effects
Structure-Activity Relationship

Substances

Amino Acids
Anesthetics, Intravenous
Esters
GABA-A Receptor Antagonists
Phenols
Propofol