Synthesis and hybridization property of novel 2',5'-isoDNA mimic chiral peptide nucleic acids

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1041-3. doi: 10.1016/s0960-894x(03)00075-1.

Abstract

2',5'-isoDNA mimic chiral peptide nucleic acid (isoPNA) monomers derived from D- and L-aspartic acids were synthesized. These novel monomers were incorporated in aminoethylglycine peptide nucleic acid (aegPNA) thymine dodecamers, and the hybridization properties to RNA and DNA were demonstrated by UV thermal denaturation.

MeSH terms

  • Aspartic Acid / chemistry
  • DNA, Complementary / biosynthesis
  • DNA, Complementary / genetics
  • Dipeptides / chemistry
  • Hot Temperature
  • Molecular Mimicry*
  • Nucleic Acid Hybridization
  • Peptide Nucleic Acids / chemistry*
  • Peptide Nucleic Acids / genetics
  • Protein Denaturation
  • RNA, Complementary / biosynthesis
  • RNA, Complementary / genetics
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Ultraviolet Rays

Substances

  • DNA, Complementary
  • Dipeptides
  • Peptide Nucleic Acids
  • RNA, Complementary
  • Aspartic Acid
  • N-glycylalanine