Abstract
The susceptibility or resistance of clinical isolates of Mycobacterium tuberculosis were determined by a method incorporating the 2,3-bis(2-methoxy-4-nitro-5-sulphophenyl)-2H-tetrazolium-5-carboxanilide (XTT) and compared with results obtained by the National Committee for Clinical Laboratory Standards approved standard method (M24-T2). One hundred percent of all isolates demonstrated agreement between the susceptibility and resistance to isoniazid, rifampicin, and ethambutol obtained by the two methods, suggesting that the XTT-based method could provide a useful means for the rapid determination of antimycobacterial susceptibility of clinical isolates of M. tuberculosis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology
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Colony Count, Microbial
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Colorimetry / methods
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Drug Resistance, Bacterial
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Humans
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In Vitro Techniques
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Microbial Sensitivity Tests / methods*
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Microbial Sensitivity Tests / standards
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / growth & development
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Mycobacterium tuberculosis / isolation & purification
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Tetrazolium Salts
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Tuberculosis, Multidrug-Resistant / drug therapy
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Tuberculosis, Multidrug-Resistant / microbiology
Substances
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Antitubercular Agents
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Tetrazolium Salts
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2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide