Dioxins are one of the accumulative endocrine disruptors that are detected from the human body. They are known to induce a wide range of adverse effects, however there are only a few methods that have been reported to reduce them. Consequently, a new effective method to reduce the dioxins in our body needs to be developed. To develop such a method, animal models are needed to be experimented on in order to evaluate each method required. In this study, an animal model using guinea pigs was made to evaluate the methods. Three weeks after the administration of 0.05 microg/kg/day of TCDD for 5 days, the serum TCDD level in the guinea pigs was almost equal to the relatively high dioxin level among human serum. Our present study suggests that the guinea pig model used in this research can be effective for further study in the method to reduce accumulated dioxins in the body.