Abstract
[structure: see text] This manuscript describes our synthesis of the F-H subunit of gambierol. In addition to the synthesis of the tricycle, of note is an interesting protecting group influence on the generation of a C(23) C-glycoside as well as the use of ring-closing metathesis to generate a tetrasubstituted enol ether.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Ciguatoxins*
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Cyclization
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Dinoflagellida / chemistry*
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Ethers, Cyclic / chemical synthesis*
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Glycosides / chemistry*
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Indicators and Reagents
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Oxidation-Reduction
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Polycyclic Compounds / chemical synthesis*
Substances
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Ethers, Cyclic
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Glycosides
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Indicators and Reagents
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Polycyclic Compounds
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gambierol
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Ciguatoxins