Abstract
Granulomatous vasculitis is a subset of systemic necrotizing vasculitis and has granulomatous inflammation as the main histopathologic feature. Etiopathogenesis remains poorly understood, although recent advances suggest an important role for certain pro-inflammatory cytokines, such as tumor necrosis factor-alpha. They are a heterogeneous group of clinical disorders with protean manifestations. Serologic abnormalities are present, and the presence of granular cytoplasmic staining-antineutrophil cytoplasmic antibodies is most important and is particularly useful for the diagnosis of active Wegener's granulomatosis. Corticosteroids and cyclophosphamide remain very useful in the treatment of most of these disorders.
MeSH terms
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Churg-Strauss Syndrome / diagnosis
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Churg-Strauss Syndrome / etiology
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Churg-Strauss Syndrome / therapy
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Clinical Trials as Topic
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Diagnosis, Differential
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Giant Cell Arteritis / diagnosis
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Giant Cell Arteritis / etiology
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Giant Cell Arteritis / therapy
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Granulomatosis with Polyangiitis / diagnosis
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Granulomatosis with Polyangiitis / etiology
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Granulomatosis with Polyangiitis / therapy
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Humans
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Immunosuppressive Agents / therapeutic use
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Takayasu Arteritis / diagnosis
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Takayasu Arteritis / etiology
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Takayasu Arteritis / therapy
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Vasculitis* / diagnosis
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Vasculitis* / etiology
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Vasculitis* / therapy
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Vasculitis, Central Nervous System* / diagnosis
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Vasculitis, Central Nervous System* / etiology
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Vasculitis, Central Nervous System* / therapy