Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen-positive patients

Henry Lik-Yuen Chan; May Ling Wong; Alex Yui Hui; Lawrence Cheung-Tsui Hung; Francis Ka-Leung Chan; Joseph Jao-Yiu Sung

doi:10.1128/JCM.41.3.1277-1279.2003

Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen-positive patients

J Clin Microbiol. 2003 Mar;41(3):1277-9. doi: 10.1128/JCM.41.3.1277-1279.2003.

Authors

Henry Lik-Yuen Chan¹, May Ling Wong, Alex Yui Hui, Lawrence Cheung-Tsui Hung, Francis Ka-Leung Chan, Joseph Jao-Yiu Sung

Affiliation

¹ Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. hlychan@hotmail.com

Abstract

One hundred forty-six hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients were followed up for 32 +/- 13 months. All six patients with hepatocellular carcinoma had hepatitis B virus (HBV) genotype C. Disease activity was greater in patients infected by HBV genotype C than in those infected by HBV genotype B in the HBeAg-positive phase but not after HBeAg seroconversion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antigens, Viral / analysis
Carcinoma, Hepatocellular / etiology
Disease Progression
Female
Genotype
Hepatitis B / complications
Hepatitis B / pathology*
Hepatitis B e Antigens / analysis*
Hepatitis B virus / classification
Hepatitis B virus / genetics
Hepatitis B virus / pathogenicity*
Humans
Male

Substances

Antigens, Viral
Hepatitis B e Antigens