[Primitive study of the cell lineage and Epstein-Barr virus infection in so called malignant histiocytosis with tissue microarray technique]

Changli Lu; Weiping Liu; Jia Guo; Gandi Li; Fengyuan Li

[Primitive study of the cell lineage and Epstein-Barr virus infection in so called malignant histiocytosis with tissue microarray technique]

Zhonghua Bing Li Xue Za Zhi. 2002 Dec;31(6):497-501.

[Article in Chinese]

Authors

Changli Lu¹, Weiping Liu, Jia Guo, Gandi Li, Fengyuan Li

Affiliation

¹ Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

PMID: 12622898

Abstract

Objective: To investigate the cell lineage and Epstein-Barr virus infection in previously diagnosed cases of malignant histiocytosis (MH) with tissue microarray technique.

Methods: Using tissue-chips, immunohistochemical staining, in situ hybridization and PCR to analyze 5 autopsy cases of MH.

Results: (1) In all 5 cases, positive reactions of CD45RO, CD3 epsilon, TIA-1, Granzyme B were detected in the neoplastic cells, whereas negative reactions were found with CD30, CD20, CD56. (2) All cases revealed EBER1/2 positivity in neoplastic cells.

Conclusion: Previously diagnosed malignant histiocytosis is an EBV-associated aggressive NK/T cell lymphoma.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Epstein-Barr Virus Infections / pathology*
Female
Histiocytic Sarcoma / pathology*
Histiocytic Sarcoma / virology
Humans
Immunohistochemistry
In Situ Hybridization
Lymphoma, T-Cell / immunology
Male
Polymerase Chain Reaction