Biodegradable thermoresponsive poly(amino acid)s

Yoichi Tachibana; Motoichi Kurisawa; Hiroshi Uyama; Toyoji Kakuchi; Shiro Kobayashi

doi:10.1039/b210181e

Biodegradable thermoresponsive poly(amino acid)s

Chem Commun (Camb). 2003 Jan 7:(1):106-7. doi: 10.1039/b210181e.

Authors

Yoichi Tachibana¹, Motoichi Kurisawa, Hiroshi Uyama, Toyoji Kakuchi, Shiro Kobayashi

Affiliation

¹ Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan.

PMID: 12610988
DOI: 10.1039/b210181e

Abstract

Reaction of poly(succinimide) with a mixture of 5-aminopentanol and 6-aminohexanol produced new thermoresponsive polymers based on biodegradable poly(amino acids)s, poly(N-substituted alpha/beta-asparagine)s, showing a clear LCST in water.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aspartic Acid / analogs & derivatives*
Aspartic Acid / chemistry
Biocompatible Materials / chemical synthesis*
Biocompatible Materials / chemistry*
Drug Carriers / chemical synthesis
Drug Carriers / chemistry
Hot Temperature
Peptides / chemical synthesis*
Peptides / chemistry*

Substances

Biocompatible Materials
Drug Carriers
Peptides
polyasparagine
poly-DL-succinimide
Aspartic Acid