Non-cyclic and developmental stage-specific expression of circadian clock proteins during murine spermatogenesis

Biol Reprod. 2003 Jul;69(1):81-91. doi: 10.1095/biolreprod.102.011833. Epub 2003 Feb 19.

Abstract

The central circadian clock in mammals is housed in the brain and is based on cyclic transcription and translation of clock proteins. How the central clock regulates peripheral organ function is unclear. However, cyclic expression of circadian genes in peripheral tissues is well established, suggesting that these tissues have their own endogenous oscillators. Reproduction is a process influenced by circadian rhythms in many organisms, thus making the testis an attractive model for studying clock function in peripheral organs. However, results addressing cyclic expression of clock genes in the mammalian testis are inconsistent. To resolve this issue, RNA was extracted from testes of mice at various times of day. Expression of the circadian clock genes mPer1, mPer2, Bmal1, Clock, mCry1, and Npas2 was constant at all times. Immunohistochemical localization of mPER1 and CLOCK proteins revealed restricted expression only in cells at specific developmental stages of spermatogenesis. For mPER1, these stages are the spermatogonia and the condensing spermatids. In contrast, CLOCK expression was restricted to round spermatids, specifically within the developing acrosome. Expression of mPER1 and CLOCK was constant at all times of day. These results suggest that clock proteins have noncircadian functions in spermatogenesis. Noncircadian expression of clock genes was also found in the thymus, which, like the testis, is composed primarily of differentiating cells. We propose that cyclic expression of clock genes is suspended during cellular differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acrosome / metabolism
  • Animals
  • CLOCK Proteins
  • Cell Cycle Proteins
  • Circadian Rhythm / genetics*
  • Circadian Rhythm / physiology
  • Gene Expression Regulation, Developmental
  • Immunohistochemistry
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Period Circadian Proteins
  • RNA / genetics
  • RNA / metabolism
  • Spermatogenesis / genetics*
  • Spermatogenesis / physiology
  • Testis / metabolism
  • Thymus Gland / metabolism
  • Trans-Activators / genetics*
  • Trans-Activators / metabolism

Substances

  • Cell Cycle Proteins
  • Nuclear Proteins
  • Per1 protein, mouse
  • Period Circadian Proteins
  • Trans-Activators
  • RNA
  • CLOCK Proteins
  • Clock protein, mouse