Abstract
Simplakidine A, a unique 4-alkyl-substituted pyridiunium alkaloid, has been isolated from the Caribbean sponge Plakortis simplex. The stereostructure of simplakidine A has been determined using MS and NMR data, molecular mechanics, and an extension of the J-based configuration analysis. Data about the growth-inhibition activity of simplakidine A are reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Animals
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Cell Line
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Macrophages / drug effects
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Porifera / chemistry*
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Pyridinium Compounds / chemistry*
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Pyridinium Compounds / isolation & purification
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Pyridinium Compounds / pharmacology
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Spectrometry, Mass, Electrospray Ionization / methods
Substances
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Alkaloids
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Pyridinium Compounds
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simplakidine A