Simplakidine A, a unique pyridinium alkaloid from the Caribbean sponge plakortis simplex

Org Lett. 2003 Mar 6;5(5):673-6. doi: 10.1021/ol027437r.

Abstract

Simplakidine A, a unique 4-alkyl-substituted pyridiunium alkaloid, has been isolated from the Caribbean sponge Plakortis simplex. The stereostructure of simplakidine A has been determined using MS and NMR data, molecular mechanics, and an extension of the J-based configuration analysis. Data about the growth-inhibition activity of simplakidine A are reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Animals
  • Cell Line
  • Macrophages / drug effects
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Porifera / chemistry*
  • Pyridinium Compounds / chemistry*
  • Pyridinium Compounds / isolation & purification
  • Pyridinium Compounds / pharmacology
  • Spectrometry, Mass, Electrospray Ionization / methods

Substances

  • Alkaloids
  • Pyridinium Compounds
  • simplakidine A