For some years now there has been a systematic increase in the number of reports on new secondary metaholites of truxillic and truxinic acid derivatives. The paper offers a presentation of existing forms of cyclobutanodicarhoxylic acids in plant kingdom. while considering their stereochemical structure and hiosynthesis. Also presented are some results of research on the pharmacological activity of synthetic and natural derivatives of these compounds. The paper shows additionally the results of search in nature for compounds containing fragments of truxillic and truxinic acids seen against the occurrence of other compounds of cyclobutane derivatives in plant kingdom.