Abstract
Extravasations of chemotherapeutic drugs may lead to large soft-tissue losses in the hand and forearm and necessitating surgical excision with secondary flap coverage. Unfortunately, a delayed referral to a hand and plastic surgical unit with an already established soft-tissue defect is most common. Nevertheless, in our unit the method of choice is early emergency subcutaneous "wash-out", which facilitates dilution and reduction of concentration of the extravasation and therefore reliably avoids the development of soft-tissue defects. The aim of this paper is to present the surgical technique.
MeSH terms
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Anesthesia, Conduction
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / pharmacokinetics
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Burns, Chemical / surgery*
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Capillary Permeability / drug effects
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Dimethyl Sulfoxide / administration & dosage
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Emergencies*
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Extravasation of Diagnostic and Therapeutic Materials / surgery*
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Forearm Injuries / chemically induced*
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Forearm Injuries / surgery
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Hand Injuries / chemically induced*
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Hand Injuries / surgery
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Humans
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Hyaluronoglucosaminidase / administration & dosage
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Infusions, Intravenous
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Isotonic Solutions / administration & dosage
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Ringer's Lactate
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Sodium Chloride
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Therapeutic Irrigation / methods*
Substances
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Antineoplastic Agents
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Isotonic Solutions
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Ringer's Lactate
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Sodium Chloride
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Hyaluronoglucosaminidase
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Dimethyl Sulfoxide