[Subcutaneous "wash-out" in extravasations]

Handchir Mikrochir Plast Chir. 2002 Nov;34(6):399-402. doi: 10.1055/s-2002-37469.
[Article in German]

Abstract

Extravasations of chemotherapeutic drugs may lead to large soft-tissue losses in the hand and forearm and necessitating surgical excision with secondary flap coverage. Unfortunately, a delayed referral to a hand and plastic surgical unit with an already established soft-tissue defect is most common. Nevertheless, in our unit the method of choice is early emergency subcutaneous "wash-out", which facilitates dilution and reduction of concentration of the extravasation and therefore reliably avoids the development of soft-tissue defects. The aim of this paper is to present the surgical technique.

MeSH terms

  • Anesthesia, Conduction
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / pharmacokinetics
  • Burns, Chemical / surgery*
  • Capillary Permeability / drug effects
  • Dimethyl Sulfoxide / administration & dosage
  • Emergencies*
  • Extravasation of Diagnostic and Therapeutic Materials / surgery*
  • Forearm Injuries / chemically induced*
  • Forearm Injuries / surgery
  • Hand Injuries / chemically induced*
  • Hand Injuries / surgery
  • Humans
  • Hyaluronoglucosaminidase / administration & dosage
  • Infusions, Intravenous
  • Isotonic Solutions / administration & dosage
  • Ringer's Lactate
  • Sodium Chloride
  • Therapeutic Irrigation / methods*

Substances

  • Antineoplastic Agents
  • Isotonic Solutions
  • Ringer's Lactate
  • Sodium Chloride
  • Hyaluronoglucosaminidase
  • Dimethyl Sulfoxide