Objective: To study on purgative activity of rhubarb extracts by solvent extraction, SFE-CO2 and SFE-CO2 & residue resin purification.
Methods: The effects of the extracts by the three technologies on creepage of mouse small intestine and rat large intestine were studied by injecting charcoal ink into the intestines. And the volume of the mouse small intestine was observed. The effects of the extracts were also studied on water absorption of mouse small intestine and large intestine by weighing the intestines.
Results: The purgative activity of the extracts by the three technologies was SFE-CO2 & residue resin purification > solvent extraction > SFE-CO2.
Conclusion: Extracting different polar components separately might get a good result.