Diastereoselective titanium enolate aldol reaction for the total synthesis of epothilones

Org Lett. 2002 Oct 31;4(22):3811-4. doi: 10.1021/ol026480b.

Abstract

[formula: see text] The development of a highly diastereoselective addition of the titanium enolate derived from ketone 1 to aldehyde 2 offers an efficient entry to the total synthesis of the epothilone family. The new aldol process is robust and tolerates a wide range of functional groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Epothilones / chemical synthesis*
  • Epothilones / chemistry
  • Stereoisomerism
  • Titanium / chemistry

Substances

  • Aldehydes
  • Antineoplastic Agents
  • Epothilones
  • Titanium
  • epothilone B