Abstract
[formula: see text] The development of a highly diastereoselective addition of the titanium enolate derived from ketone 1 to aldehyde 2 offers an efficient entry to the total synthesis of the epothilone family. The new aldol process is robust and tolerates a wide range of functional groups.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Epothilones / chemical synthesis*
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Epothilones / chemistry
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Stereoisomerism
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Titanium / chemistry
Substances
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Aldehydes
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Antineoplastic Agents
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Epothilones
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Titanium
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epothilone B