Highly enantioselective 1,4-addition of diorganozinc reagents to cyclic enones using chiral diphosphite ligands derived from H8-binaphthol

Liang Liang; Terry T L Au-Yeung; Albert S C Chan

doi:10.1021/ol026581+

Highly enantioselective 1,4-addition of diorganozinc reagents to cyclic enones using chiral diphosphite ligands derived from H8-binaphthol

Org Lett. 2002 Oct 31;4(22):3799-801. doi: 10.1021/ol026581+.

Authors

Liang Liang¹, Terry T L Au-Yeung, Albert S C Chan

Affiliation

¹ Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.

PMID: 12599462
DOI: 10.1021/ol026581+

Abstract

[formula: see text] High enantioselectivities have been achieved in the 1,4-addition of dialkylzincs to 2-cyclopentenone, 2-cyclohexenone, and 2-cycloheptenone with ee values up to 99% by using chiral aryl diphosphite ligands derived from H8-binaphthol.