Abstract
Non-B HIV-1 samples collected in France between 1999 and 2001 were sequenced in the env, reverse transcriptase (RT), and protease genes (1) to characterize further the non-B strains circulating in the country, (2) to assess the importance of recombination, and (3) to describe the polymorphism of RT and protease genes and appreciate a possible impact on susceptibility to antiretroviral (ARV) drugs. The results show that, within a background of CRF02_AG predominance, there is a high genetic diversity of non-B isolates, including intersubtype recombinants. There is an extensive polymorphism of protease and RT genes compared with B consensus sequences; we have so far no data indicating that these non-B isolates may have reduced sensitivity to ARV drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Acid Substitution
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / therapeutic use
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Drug Resistance, Viral
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Female
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France
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Genes, env / genetics*
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Genetic Variation*
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HIV Infections / drug therapy
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HIV Infections / virology*
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HIV Protease / chemistry
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HIV Protease / genetics*
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HIV Reverse Transcriptase / chemistry
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HIV Reverse Transcriptase / genetics*
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HIV-1 / classification
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HIV-1 / drug effects*
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HIV-1 / genetics*
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Humans
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Male
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Middle Aged
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Recombination, Genetic
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Reverse Transcriptase Inhibitors / pharmacology
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Reverse Transcriptase Inhibitors / therapeutic use
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Sequence Analysis, DNA
Substances
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Anti-HIV Agents
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Reverse Transcriptase Inhibitors
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HIV Reverse Transcriptase
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HIV Protease