Abstract
The LDB1 gene of Saccharomyces cerevisiae was identified by complementation of the ldb1 mutant phenotype with a genomic library. We found that the ldb1 defect is complemented by PMR1 which codes for the yeast secretory pathway/Golgi Ca(2+)/Mn(2+)-ATPase. Besides that, the analysis of a null mutation of the PMR1 gene revealed a phenotype identical to that of ldb1 mutant. Thus, LDB1 must be considered a synonym of PMR1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Calcium / metabolism
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Calcium-Transporting ATPases / deficiency*
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Calcium-Transporting ATPases / genetics
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Calcium-Transporting ATPases / metabolism
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Gene Expression Regulation, Enzymologic
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Gene Expression Regulation, Fungal
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Genetic Complementation Test
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Golgi Apparatus / enzymology*
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Manganese / metabolism
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Mutation*
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Saccharomyces cerevisiae / enzymology*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / growth & development
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Saccharomyces cerevisiae Proteins / genetics*
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Saccharomyces cerevisiae Proteins / metabolism
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Transformation, Genetic
Substances
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Saccharomyces cerevisiae Proteins
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Manganese
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Calcium-Transporting ATPases
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Calcium