Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring

Eur J Med Chem. 2003 Jan;38(1):65-74. doi: 10.1016/s0223-5234(02)00007-7.

Abstract

Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). Most of them maintained their cytotoxicity at the microM level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor / drug effects
  • Dioxanes / chemical synthesis
  • Dioxanes / pharmacology
  • Dioxoles / chemical synthesis
  • Dioxoles / chemistry
  • Dioxoles / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Lignans / chemical synthesis*
  • Lignans / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Models, Chemical
  • Molecular Structure
  • Podophyllotoxin / analogs & derivatives*
  • Podophyllotoxin / pharmacology
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Dioxanes
  • Dioxoles
  • Lignans
  • 1,3-benzodioxole
  • Podophyllotoxin