Abstract
Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). Most of them maintained their cytotoxicity at the microM level.
Copyright 2002 Editions scienctifiques et médicales Elsevier SAS
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor / drug effects
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Dioxanes / chemical synthesis
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Dioxanes / pharmacology
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Dioxoles / chemical synthesis
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Dioxoles / chemistry
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Dioxoles / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Lignans / chemical synthesis*
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Lignans / pharmacology
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Magnetic Resonance Spectroscopy
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Mice
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Models, Chemical
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Molecular Structure
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Podophyllotoxin / analogs & derivatives*
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Podophyllotoxin / pharmacology
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Dioxanes
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Dioxoles
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Lignans
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1,3-benzodioxole
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Podophyllotoxin