[Preparation of tea polyphenols sustained-release microcapsule]

Zhong Yao Cai. 2000 May;23(5):281-4.
[Article in Chinese]

Abstract

With ethycellulose (EC) as matrix tea polyphenols (TP) microcapsule was prepared by using emulsion solvent evaporation technique. Effect of preparation condition on size and drug entrapment efficiency of microcapsule was investigated. We also investigated the drug entrapment effect of microcapsule. The result showed that the tawny microcapsule with highly porous surface was obtained by using polyvinyl alcohol (PVA) and sodium dodccyl sulate (SDS) as dispersant. The stirring rate, polymer concentration and drug payload affected the size and drug entrapment efficiency of microcapsule. The matrix and preparation method do not damage the ingredient of TP. The microcapsule can improve the stability of TP and sustain TP released.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capsules
  • Delayed-Action Preparations
  • Drug Carriers
  • Drug Delivery Systems
  • Flavonoids*
  • Phenols / administration & dosage*
  • Phenols / isolation & purification
  • Polymers / administration & dosage*
  • Polymers / isolation & purification
  • Polyphenols
  • Polyvinyl Alcohol
  • Sodium Dodecyl Sulfate
  • Tea / chemistry*
  • Technology, Pharmaceutical / methods

Substances

  • Capsules
  • Delayed-Action Preparations
  • Drug Carriers
  • Flavonoids
  • Phenols
  • Polymers
  • Polyphenols
  • Tea
  • Sodium Dodecyl Sulfate
  • Polyvinyl Alcohol