Peptide derivatives as agonists or antagonists of formylpeptide receptors: analysis of their effects on neutrophils

Mini Rev Med Chem. 2003 May;3(3):167-73. doi: 10.2174/1389557033488222.

Abstract

The effects of peptide derivatives as agonists or antagonists of formylpeptide receptors are described, taking into account the related cellular responses by neutrophils. These effects are related to the structure of peptide derivatives, some of which are potent anti HIV-1 agents. Finally, formylpeptide receptor models are depicted.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology
  • Humans
  • Neutrophils / drug effects*
  • Peptides / chemistry
  • Peptides / pharmacology*
  • Receptors, Formyl Peptide
  • Receptors, Immunologic / agonists*
  • Receptors, Immunologic / antagonists & inhibitors*
  • Receptors, Immunologic / chemistry
  • Receptors, Immunologic / metabolism
  • Receptors, Peptide / agonists*
  • Receptors, Peptide / antagonists & inhibitors*
  • Receptors, Peptide / chemistry
  • Receptors, Peptide / metabolism

Substances

  • Anti-HIV Agents
  • Peptides
  • Receptors, Formyl Peptide
  • Receptors, Immunologic
  • Receptors, Peptide