Effect of 0.2% brimonidine on retinal blood flow

Yan Ke Xue Bao. 2001 Mar;17(1):42-5.

Abstract

Purpose: To analyze the effect of 0.2% brimonidine eye drops on retinal blood flow of patients with glaucoma.

Methods: Using self-control method and Heidelberg Retina Flowmeter (HRF), we examined the volume, flow and velocity of the superior nasal and temporal, the inferior nasal and temporal artery of retina at baseline and 2 hours after single instillation of 0.2% brimonidine.

Results: There were no significant changes in volume, flow and velocity of four vessels before and after the administration of 0.2% brimonidine.

Conclusions: There are no significant ocular haemodynamic benefits associated with Brimonidine therapy to the glaucoma patients.

MeSH terms

  • Adrenergic alpha-Agonists / administration & dosage
  • Adrenergic alpha-Agonists / therapeutic use
  • Adult
  • Brimonidine Tartrate
  • Glaucoma, Open-Angle / drug therapy*
  • Glaucoma, Open-Angle / physiopathology*
  • Humans
  • Middle Aged
  • Ophthalmic Solutions
  • Quinoxalines / administration & dosage
  • Quinoxalines / therapeutic use*
  • Regional Blood Flow / drug effects
  • Retinal Vessels / physiopathology*

Substances

  • Adrenergic alpha-Agonists
  • Ophthalmic Solutions
  • Quinoxalines
  • Brimonidine Tartrate