Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma

Cancer Lett. 2003 Feb 20;190(2):191-7. doi: 10.1016/s0304-3835(02)00590-6.

Abstract

Drug resistance is a common clinical problem in cancer treatment. The overexpression of P-glycoprotein appears to be closely associated with multi-drug resistance to anticancer agents. YB-1 binds to the Y-box in the promoter region of MDR1, which encodes P-glycoprotein. We evaluated the correlation between nuclear YB-1 and P-glycoprotein expression and other molecules, such as hormonal receptors, angiogenic factors, immune factors, and methalloprotease in 63 human breast cancers. Nuclear YB-1 expression had a significant correlation with P-glycoprotein and PgR expression, and also with CD68 grade, concerning accumulation of tumor associated macrophages. This series did not demonstrate P-glycoprotein and nuclear YB-1 expression might be one of the useful prognostic marker of breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • CCAAT-Enhancer-Binding Proteins / metabolism*
  • Cell Nucleus / metabolism*
  • DNA-Binding Proteins*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Middle Aged
  • NFI Transcription Factors
  • Nuclear Proteins
  • Prognosis
  • Survival Analysis
  • Transcription Factors*
  • Y-Box-Binding Protein 1

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • CCAAT-Enhancer-Binding Proteins
  • DNA-Binding Proteins
  • NFI Transcription Factors
  • Nuclear Proteins
  • Transcription Factors
  • Y-Box-Binding Protein 1
  • YBX1 protein, human