Objective: To observe the effectiveness of levofloxacin and cefuroxime for the treatment of sinusitis in adults.
Method: Patients with acute or chronic sinusitis were randomly assigned to receive either levofloxacin (200 mg orally once daily, 200/100 mg twice daily) or cefuroxime (250 mg orally twice daily) for 10 to 14 days. Pre- or post-treatment, the clinical and laboratory examination were done and in the end of treatment, the efficacy and safety were assessment.
Result: The success rates after the end of treatment were 97.4% for the 76 patients who received levofloxacin and 92.8% for the 14 patients who received cefuroxime. The resolution rates of bacteria were 91.6% and 80.0%, respectively. The safety of these two groups were more high.
Conclusion: Levofloxacin is effective for the treatment of sinusitis in adults and pay attention to the course of treatment for raising the efficacy of treatment.