CD40 in hepatocellular carcinoma: relevant or not?

Eur J Gastroenterol Hepatol. 2003 Feb;15(2):113-4. doi: 10.1097/00042737-200302000-00001.

Abstract

The expression of the CD40 receptor in different tumours suggests that it might be involved in tumour development and proliferation. In this article, we discuss recent findings on CD40 expression in hepatocellular carcinoma, its possible biological role for tumour development, and different experimental therapeutic strategies such as gene therapy and immunotherapy protocols.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, Neoplasm / analysis
  • Antigens, Neoplasm / physiology
  • CD40 Antigens / analysis
  • CD40 Antigens / physiology*
  • Carcinoma, Hepatocellular / immunology
  • Carcinoma, Hepatocellular / metabolism*
  • Cell Transformation, Neoplastic
  • Genetic Therapy
  • Humans
  • Immunotherapy
  • Ligands
  • Liver Neoplasms / immunology
  • Liver Neoplasms / metabolism*
  • Rats
  • Tumor Cells, Cultured

Substances

  • Antigens, Neoplasm
  • CD40 Antigens
  • Ligands