Abstract
In the course of our search for new antiplasmodial alkaloids from Strychnos icaja, we have isolated five alkaloids: three monomers, protostrychnine and genostrychnine, previously described in Strychnos nux-vomica, pseudostrychnine, already found in the leaves of the plant, a new bisindolic alkaloid, named strychnogucine C, and the first naturally occurring trimeric indolomonoterpenic alkaloid: strychnohexamine. This latter trimeric alkaloid presented an antiplasmodial activity against the FCA Plasmodium falciparum line near 1 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Carbazoles / chemistry
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Carbazoles / isolation & purification*
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Carbazoles / pharmacology
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Democratic Republic of the Congo
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Monoterpenes / chemistry
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Monoterpenes / isolation & purification*
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Monoterpenes / pharmacology
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Plant Roots / chemistry
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Plasmodium falciparum / drug effects*
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Stereoisomerism
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Strychnine / analogs & derivatives
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Strychnine / chemistry
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Strychnine / isolation & purification*
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Strychnine / pharmacology
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Strychnos / chemistry*
Substances
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Antimalarials
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Carbazoles
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Indole Alkaloids
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Monoterpenes
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strychnohexamine
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Strychnine