A new HLA-DRB allele (DRB1*15014) identified in a Caucasian individual

Hum Immunol. 2003 Feb;64(2):310-3. doi: 10.1016/s0198-8859(02)00779-6.

Abstract

Polymerase chain reaction with sequence specific primers subtyping of a DRB1*15 allele in a male 11-year-old German Caucasian and his father revealed a reaction pattern that did not agree with any known specificity, thus suggesting the existence of a novel allele. Sequence-based typing after allelic separation revealed the new allele human leukocyte antigen (HLA)-DRB1*15014. The sequence pattern of HLA-DRB1*15014 might have been generated as a result of two independent recombinations, most likely over several generations.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Alleles*
  • Asian People / genetics
  • Base Sequence
  • Child
  • Gene Frequency
  • Genes, MHC Class II*
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Humans
  • Male
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • White People / genetics*

Substances

  • HLA-DR Antigens
  • HLA-DRB1 Chains