Influence of haemoglobin concentration and peripheral muscle pO2 on tumour oxygenation in advanced head and neck tumours

Radiother Oncol. 2003 Jan;66(1):71-4. doi: 10.1016/s0167-8140(02)00391-2.

Abstract

Haemoglobin concentrations and tumour-pO(2) were evaluated pre-therapy in 30 patients with head and neck cancers. Anterior tibialis muscle-pO(2) was additionally measured in 16 of these patients. Tumour-pO(2) was lower in the most anaemic patients (P=0.032) and correlated with muscle-pO(2) (r=0.809, P<0.001). These results suggest that haemoglobin concentration influences tumour-oxygenation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / analysis
  • Cell Respiration
  • Female
  • Head and Neck Neoplasms / metabolism*
  • Head and Neck Neoplasms / pathology*
  • Head and Neck Neoplasms / surgery
  • Hemoglobins / analysis*
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Muscle, Skeletal / metabolism
  • Neoplasm Staging
  • Oxygen Consumption / physiology*
  • Predictive Value of Tests
  • Preoperative Care / methods
  • Probability
  • Prospective Studies
  • Sensitivity and Specificity

Substances

  • Biomarkers
  • Hemoglobins